Initially, white-collar workers would do implement their activities by working from the office (WFO) but later changed to working from home (WFH) during COVID-19. This study aims to analyze the effect of the pandemic on white-collar workers based on the driver-pressure-state-impact-response (DPSIR) model and semantic aspect. Respondents came from 22 provinces in Indonesia. The study used a sequential mixed methods design to reveal the significance between DPSIR components and to understand the meaning of symbols or signs. The results showed that there is a significant gender difference, specifically in the driver (D). The correlation value of P-S, S-I, and I-R in men was more significant than in women (p < 0.05). Men expressed more statements about the COVID-19 effect than did women. Theyused adverbs with adjective words, showing that the pandemic requires a proper adaptation, although, at the same time, they felt difficult, bored, and depressed. Based on these analyses, institutions need to pay more attention to the work efficiency and work-life balance of their workers.