E-learning has recently gained a tremendous amount of attention worldwide; however, this phenomenon has not been studied much from the viewpoints of its immediate beneficiaries (i.e., students and teachers). This systematic review aimed at creating a conceptual framework consisting of the most significant problems and challenges vs. opportunities and solutions associated with e-learning. In doing so, we established a corpus of post-pandemic articles. Out of 2126 original research articles published between March 2020 and March 2022, 13 were included. These sources were obtained through MetSearch and were representative of 14 countries, 2726 student participants, and 1374 educator participants. Through thematic analysis, each document was categorized under certain themes. Technical, physical, mental, interaction, assessment, and pedagogical issues, as well as proper training, IT literacy, and additional burdens on students and educators, were the main challenges and problems found in association with e-learning. The opportunities and solutions included improvements in communication, interaction, teaching, and learning, as well as accessibility, convenience, productivity, and safety.