Literary relations are the result of intercultural communication, which is based on the ancient history of mankind, which marked the beginning of the process of globalization. The article examines the historical foundations of the Kazakh-Uzbek literary relations and the peculiarities of their development. The subject of the research is Kazakh-Uzbek literary relations. The study of Kazakh and Uzbek literature is important in the context of comparative literary studies, which shows the existing common historical roots. Literary relations between them are also important, divided into chronological periods in accordance with the principles of historical development. The article uses both chronological and typological methods to identify the stages and types of literary translation in the literature of the two languages. With the help of the cultural-historical method, the historical origin of literary translation in Kazakh and Uzbek literature was determined, national characteristics influencing the created literary work, historical, genetic, and geographical factors that serve as the basis for their integration were identified.